Amiodarone, the generic of Cordarone, is a prescription medication classified as a class III antiarrhythmic agent. It used for treatment of ventricular tachycardia and ventricular fibrillation; these are disorders of the chambers of the heart (ventricles). They can cause irregularities of the heartbeat, called arrhythmias. Because amiodarone is actively working on the heart, many side effects may occur. Discuss any major concerns with your physician before initiating drug therapy. Knowing the side effects of the medication will ensure you know what to expect.
Effects on the Brain
Between three percent and 40 percent of persons who take amiodarone will experience side effects on the brain. These effects include abnormal gait, impaired memory, and impaired movement. According to the "Drug Information Handbook," dizziness, fatigue, insomnia, weakness and headache may also be present. Use caution when driving or operating heavy machinery until you know how the drug affects your function. Poor coordination and tremor are other adverse effects that can occur. If these worsen, inform your health care provider right away.
Photosensitivity
Photosensitivity, or sun sensitivity, can occur with the use of amiodarone. Up to 75 percent of individuals may experience this undesired side effect. Photosensitivity reactions include redness or itchy eruptions on the skin. About 10 percent of individuals may experience a blue-gray skin discoloration. Avoid direct sunlight and wear sunscreen while taking amiodarone. Also, wear clothing that covers the arms and legs to avoid these reactions.
Hypothyroidism
Hypothyroidism is a disease in which the thyroid gland does not produce enough thyroid hormone. Signs and symptoms of hypothyroidism include cold intolerance, weight gain without cause, changes in menstrual cycle, excessively dry skin, constipation, and fatigue. About 10 percent of individuals on amiodarone develop hypothyroidism. If you develop these symptoms, contact your physician so he can perform the proper tests and take the proper actions.
Nausea and Vomiting
Nausea and vomiting are side effects that may also occur in users of amiodarone. The "Drug Information Handbook" reports that about 10 to 33 percent of people will have nausea and vomiting. Chewing gum or sucking on lozenges may help alleviate these symptoms. If these side effects worsen or are accompanied by fever, seek immediate medical attention.
Liver Enzymes
Liver enzymes are proteins that aid the liver in performing chemical reactions. Your physician will test for these enzymes via a blood test. The amount of liver enzymes found in the blood will increase in about 15 to 50 percent of people administered amiodarone. Two enzymes, ALT (alanine aminotransferase) and AST (aspartate aminotransferase), can appear at 2 times above the normal levels. Alkaline phosphatase, another liver enzyme, may be elevated in about 10 to 40 percent of individuals. Always keep appointments with your physician to make sure you are being monitored closely and properly.
Corneal Microdeposits
Corneal microdeposits, which are tiny deposits in the cornea of the eye, can occur in over 90 percent of individuals taking the drug. About 10 percent of these people will experience vision changes. These include blurred vision or double vision, itchiness, and sensitivity to light. If these symptoms become persistent or worsen, seek medical help immediately.
References
- "Drug Information Handbook 15th Edition"; Charles F. Lacy, RPh, PharmD, FCSHP, Lora L. Armstrong, RPh, PharmD, BCPS. et al; 2007
- "Pharmacotherapy: A Pathophysiologic Approach"; Joseph T. Dipiro, Robert L. Talbert, et al; 2008
Member Comments