Benadryl is the product name of diphenhydramine hydrochloride, an antihistamine and first-generation histamine antagonist. This means the drug competes for the histamine receptors and prevent the action of histamine on bronchial smooth muscle, capillaries and the gastrointestinal tract. The action prevents bronchoconstriction, vasodilation and gastrointestinal smooth muscle spasms. Benadryl provides temporary relief of allergy symptoms and causes drowsiness.
Addiction
Although drug companies are not reporting addictive qualities to antihistamines, case studies have demonstrated addiction. Patients using large doses of the medication or consistently using antihistamines on a long-term basis exhibited some signs of addiction. Addiction also causes abnormally strong cravings for something that is psychologically or physically habit forming. According to Dr. French from Oregon Health and Sciences University and reported in eMedicine, the long-term use of diphenhydramine in a 34 year-old resulted in addiction. This gentleman had been using diphenhydramine for sedation and euphoria. The patient developed withdrawal symptoms when the drug was taken away.
Tolerance
Tolerance can develop when using antihistamines. Over time, the body requires more of the medication in order to get the same results. In some instances, more medication results in greater side effects or symptoms of toxicity. According to the U.S. National Library of Medicine, tolerance can develop even after you had previously been under good control with antihistamines.
Cardiovascular
Using Benadryl for long periods of time increases the risk of side effects. According to Pfizer, cardiovascular effects include hypotension, tachycardia, headache and palpitations. These long-term cardiovascular side effects can be dangerous if you have an underlying cardiovascular medical condition. They can impede your ability to use large equipment, drive vehicles or perform dangerous tasks. Benadryl is designed for short-term use and should only be used under the guidance of your physician.
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