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Risedronate is used to prevent and treat osteoporosis (a condition in which the bones become thin and weak and break easily) in women who have undergone menopause (change of life; end of menstrual periods) and in men and women who are taking glucocorticoids (corticosteroids; a type of medication that may cause osteoporosis). Risedronate is also used to treat osteoporosis in men. Risedronate is also used to treat Paget's disease of bone (a condition in which the bones are soft and weak and may be deformed, painful, or easily broken). Risedronate is in a class of medications called bisphosphonates. It works by preventing bone breakdown and increasing bone density (thickness).

How

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

You must take risedronate immediately after you get out of bed in the morning and before you eat or drink anything. Never take risedronate at bedtime or before you wake up and get out of bed for the day.

Swallow the tablets with a full glass (6 to 8 ounces) of plain water while you are sitting or standing. Never take risedronate with tea, coffee, juice, mineral water, milk, other dairy drinks, or any liquid other than plain water.

Swallow the tablets whole. Do not split, chew, or crush them. Do not suck on the tablets or hold them in your mouth for any length of time.

After you take risedronate, do not eat, drink, or take any other medications for at least 30 minutes. Do not lie down for at least 30 minutes after you take risedronate. Sit upright or stand upright until at least 30 minutes have passed.

Side Effects

nausea

burping

dry mouth

stomach pain

diarrhea

constipation

headache

dizziness

depression

anxiety

weakness

leg cramps

bone, joint, and/or muscle pain

back pain

flu-like symptoms

fever, chills, sore throat, cough, and other signs of infection

frequent or urgent need to urinate

painful urination

runny nose

dry eyes

ringing in the ears

Risedronate may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

MedWatch

Precautions

Before taking risedronate,

tell your doctor and pharmacist if you are allergic to risedronate or any other medications.

tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn);cancer chemotherapy;and oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

if you are taking any other oral medications including vitamins, supplements, or antacids, take them at least 30 minutes after you take risedronate.

tell your doctor if you have or have ever had a low level of calcium in your blood and if you are unable to sit upright or stand upright for at least 30 minutes. Your doctor may tell you that you should not take risedronate.

tell your doctor if you are undergoing radiation therapy; if you have or have ever had difficulty swallowing; heartburn, ulcers, or other problems with your stomach or esophagus; anemia (condition in which the red blood cells do not bring enough oxygen to all the parts of the body); cancer; any type of infection, especially in your mouth; problems with your mouth, teeth, or gums; any condition that stops your blood from clotting normally; dental or kidney disease.

tell your doctor if you are pregnant or are breast-feeding. Also tell your doctor if you plan to become pregnant at any time in the future, because risedronate may remain in your body for years after you stop taking it. Call your doctor if you become pregnant during or after your treatment with risedronate.

you should know that risedronate may cause serious problems with your jaw, especially if you have dental surgery or treatment while you are taking the medication. A dentist should examine your teeth and perform any needed treatments before you start to take risedronate. Be sure to brush your teeth and clean your mouth properly while you are taking risedronate. Talk to your doctor before having any dental treatments while you are taking this medication.

talk to your doctor about other things you can do to prevent osteoporosis from developing or worsening. Your doctor will probably tell you to avoid smoking and drinking large amounts of alcohol and to follow a regular program of weight-bearing exercise.

Overdose

In case of overdose, give the victim a full glass of milk and call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

numbness or tingling around mouth or in hands or feet

muscle spasms, cramps, or twitches

seizures

What If I Forget

If you miss a dose of once-daily risedronate, do not take it later in the day. Skip the missed dose and take one dose the next morning as usual. If you miss a dose of once-weekly risedronate, do not take it later in the day. Take one dose the morning after you remember. Then return to taking one dose once each week on your regularly scheduled day. Never take a double dose to make up for a missed one, and never take more than one dose in one day.

Storage

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

Dietary Restrictions

You should eat plenty of foods that are rich in calcium and vitamin D while you are taking risedronate. Your doctor will tell you which foods are good sources of these nutrients and how many servings you need each day. If you find it difficult to eat enough of these foods, tell your doctor. In that case, your doctor can prescribe or recommend a supplement.

Miscellaneous

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Other Uses

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

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