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Aciphex Compared to Nexium

author image Esther Kinuthia RN BSN BA
Esther Kinuthia is a registered nurse with extensive experience in health and wellness. She holds a B.S. in nursing, B.A in psychology and has worked for more than ten years in the health-care field. She enjoys writing articles on a variety of topics for the Internet. Her work has been published in various websites.
Aciphex Compared to Nexium
A male pharmacist discusses medication with a female customer. Photo Credit: Wavebreakmedia/iStock/Getty Images

The generic name for Aciphex is raberprazole sodium, while Nexium's generic name is esomeprazole magnesium. Aciphex and Nexium belong to a class of medications known as proton pump inhibitors. Proton pump inhibitors block the work of hydrogen potassium ATPase, an enzyme that stimulates production of stomach acid. Nexium and Aciphex have some similarities and differences

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According to, Aciphex is used to treat persistent heartburn due to gastroesophageal reflux disease. Aciphex is also used together with amoxillin and clarithyromycin antibiotics to treat ulcers caused by helicobacter pylori. According to, Nexium is used to treat erosive esophagitis caused by gastroesophageal reflux disease. Nexium is also prescribed to patients who take nonstreoidal noninflammatory drugs in order to prevent stomach irritation. Aciphex and Nexium are also used to treat Zollinger-Ellison syndrome, a condition in which the stomach produces too much acid.


According to, Nexium should not be used by patients who are allergic to esomeprazole magnesium. Aciphex should also not be prescribed to patients allergic to raberprazole sodium. Signs and symptoms of allergic reactions to Nexium and Aciphex include chest pain, wheezing, swelling of the face and mouth, hives and rashes. Patients who experience allergic reactions after taking Nexium should seek immediate medical attention.


Nexium and Aciphex should be used carefully in patients with impaired renal and hepatic function. Nexium and Aciphex are metabolized in the liver and removed from the body by the kidneys. Patients who have kidney and liver problems may have problems removing the drugs from the body leading to drug toxicity. Patients should inform their doctors of all past medical histories to avoid complications.

Side Effects

According to, common side effects of Aciphex include pharyngitis, flatulence, constipation, headache, diarrhea, nausea, vomiting, abdominal pain, sore throat and dizziness. According to, common side effects of Nexium include headache, dry cough nausea, flatulence, diarrhea, dry mouth, constipation, abdominal pain and vomiting. Adverse side effects of Nexium and Aciphex include liver damage, growth of fungus in the esophagus and mouth and growth of cancerous stomach polyps.

Directions of Use states that Aciphex tablets are usually taken once a day with or without food. Patients should swallow Aciphex delayed-release tablets whole without crushing, breaking or chewing. According to, Nexium delayed-release capsules should be swallowed whole one hour before meals. Patients having swallowing problems may open Nexium capsules and pour pellets on applesauce, and swallow it immediately without chewing.

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