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Side Effects of Proin

author image Rae Uddin
Rae Uddin has worked as a freelance writer and editor since 2004. She specializes in scientific journalism and medical and technical writing. Her work has appeared in various online publications. Uddin earned her Master of Science in integrated biomedical sciences with an emphasis in molecular and cellular biochemistry from the University of Kentucky College of Medicine.
Side Effects of Proin
A dog at the vet. Photo Credit: Jupiterimages/Digital Vision/Getty Images

Proin is a veterinarian-prescribed medication for dogs that contains the active ingredient phenylpropanolamine. This medication is indicated to alleviate symptoms associated with urinary incontinence, a condition in which a dog is unable to voluntarily control urine production. Proin works by increasing the tone of the urethral wall and bladder, which helps prevent urine leakage. Dog owners should discuss the side effects of Proin with a veterinarian before giving this medication to their dog.

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Restlessness or Irritability

While receiving treatment with Proin, a dog may appear unusually restless or irritable, reports. He may be more playful than usual or may need to be walked more frequently to release excess energy. Side effects of restlessness or irritability may make it difficult for a dog to nap or fall asleep. These side effects of Proin are temporary and may progressively subside with continued use of this medication.

Increased Heart Rate or Blood Pressure

Dogs taking Proin may develop an unusually increased heart rate as a side effect of treatment, PetCareRx warns. Certain dogs may also develop hypertension, a condition characterized by increased blood pressure. Dogs that exhibit heart-related side effects while receiving treatment with this medication should be evaluated by a veterinarian.

Diminished Appetite

Appetite loss may occur in dogs taking Proin, reports. Affected dogs may be uninterested in eating their favorite snack or meal and may leave their food bowl untouched. If appetite changes persist or occur in conjunction with vomiting, affected dogs should receive further evaluation and care from a veterinarian.

Allergic Reaction

Dogs that are allergic to phenylpropanolamine or any of the components of Prion should not be treated with this medication. Improper use of Proin by hypersensitive dogs may induce a severe and potentially life-threatening allergic reaction. Symptoms of a hypersensitive reaction in dogs include weakness, seizures, pale gums, facial swelling and difficulty breathing. Dogs who exhibit any of these side effects after taking a dose of Prion should be transported to an emergency veterinarian clinic immediately.

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