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What Are the Causes of Infiltration of Lungs?

author image Valerie Liles
Based in Atlanta, Valerie Liles has been writing about landscape and garden design since 1980. As a registered respiratory therapist, she also has experience in family health, nutrition and pediatric and adult asthma managment. Liles holds a Bachelor of Arts in journalism from Colorado State University and a Master of Science in technical communication from the University of Colorado.
What Are the Causes of Infiltration of Lungs?
Shortness of breath is a tell-tale sign of pulmonary infiltrates.

Lung disorders such as pneumonia, silicosis, asbestosis and cystic fibrosis often cause the air sacs or alveoli to fill with fluids comprised of white blood cells, cancer cells, pus, proteins or blood. These substances are called infiltrates. Depending on the severity of the condition, these infiltrates can involve a small area of the lung causing minor symptoms or completely fill an entire region of the lung causing a serious, life-threatening condition.

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This bacterial infection not only affects the lungs, but it can affect other parts of the body, as well. According to MedlinePlus, the lungs become severely inflamed causing differing levels of irreversible damage regardless of the treatment. Primary symptoms include fever and coughing with mucus production. Pus collects in the pleural space, a condition known as empyema.

Acute Respiratory Distress Syndrome

Acute respiratory distress syndrome, or ARDS, is a serious illness that usually leads to respiratory failure. According to the National Heart Lung and Blood Institute, ARDS is a nonspecific disease related to severe pneumonia, shock, sepsis and trauma. ARDS often requires immediate medical intervention because of respiratory insufficiency. As the air sacs fill with fluid from infection, the condition severely reduces the lungs’ ability to collect and distribute oxygen to the cells. The lungs become stiff and difficult to ventilate leading to severe shortness of breath.


A variety of bacteria can cause pneumonia. The most common cause of bacterial pneumonia is Streptococcus pneumoniae. Symptoms include headache, loss of appetite, fever, sweating, and joint and muscle pain. Coughing, chest pain, and shortness of breath soon follow as the lungs’ smallest airways and alveoli become inflamed from the infection. According to the University of Maryland Medical Center, the scattered infiltrates reveal a massive influx of white blood cells that attack the invading bacteria, producing pus. People with this infection often cough up green or yellow mucus, sometimes streaked with blood.

Pulmonary Edema

Pulmonary edema is a collection of fluid in the lung tissue and alveoli because of increased pressure within the capillaries, the tiny blood vessels within the lungs, causing them to leak. According to, pulmonary edema is most often the result of heart disease and heart failure, kidney failure and hypertension. Pulmonary edema can also occur from inhaling toxic gases, from smoke inhalation from severe pneumonia and shock. The lungs fill with frothy, pink-tinged secretions severely limiting a person’s ability to breathe. Without treatment, people can essentially drown in their own secretions.

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