Side Effects of Estrace Cream

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Estrace Cream is a vaginal cream containing the estrogen hormone. The prescription medication works to balance postmenopausal changes in a woman’s vagina. Common conditions treated with Estrace Cream include vaginal dryness, itching and painful intercourse. Although Estrace Cream is used vaginally, the medication can be absorbed into the body and affect other areas of the body, causing unwanted adverse reactions. Some serious side effects may occur while using the medication. Women need full medical examinations with a complete medical history before starting any hormone replacement therapy program.

Common Side Effects

Breast tenderness and pain, enlarged breasts, headaches, bloating, stomach cramping, nausea or vomiting. The medication may cause a loss of hair, weight changes, dizziness, bloating and mood swings. A restart of vaginal bleeding can occur after beginning the use of Estrace Cream. The medicine can cause bleeding as heavy as a menstrual period or spotting. Women currently still experiencing a menstrual period may experience breakthrough bleeding or other change in normal bleeding patterns. Some women may experience a change in libido, either an increase or a decrease.

Less Common Side Effects

Some women may experience an infection, such as vaginitis or yeast. Abdominal pain, cramping and diarrhea can occur during Estrace Cream use. Less common reactions includes inflammation of the pancreas and gallbladder disease. Some women may have changes in the shape of the eyes, causing an inability to wear contact lenses.

Serious Side Effects

Using Estrace Cream has the potential to cause serious, life threatening side effects. A study in 2002, conducted by the Women’s Health Initiative, concluded that taking estrogen increases the chance of developing uterine cancer, breast cancer, stroke, heart disease, heart attacks and blood clots.


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