Glutathione And Depression

Major depression is more than a "down in the dumps" feeling that many experience for short periods of time due to fatigue and stress. Individuals with true clinical depression experience these symptoms along with thoughts of suicide, appetite changes and self-hate for prolonged periods of time that interfere with a person's ability to perform everyday activities. After diagnosing depression, the doctor may prescribe anti-depressant medications along with behavior-cognitive therapy and psychotherapy to treat the condition. Certain over-the-counter supplements that enhance glutathione levels in the body may also help manage depression; however, seek your physician's advice before taking glutathione.

What is Glutathione?

Glutathione is tripeptide made up of three amino acids -- glycine, L-cysteine and L-glutamate. It is produced in the liver and plays a major role in tissue building and repair as well as in the proper functioning of the immune system. It is one of the most powerful antioxidants in the body and helps scavenge the free radicals formed as a result of various metabolic processes in the body. The unstable free radicals interact with the DNA and proteins of the cells, cause cellular damage and leads to many chronic conditions.

Link between Glutathione and Depression

Studies such as the one published in the July 2008 issue of the journal "Trends in Pharmacological Sciences" suggest that free radical-mediated oxidative stress is one of the main causes for the pathophysiological mechanisms that contribute to psychiatric disorders such as depression. Glutathione, with its significant antioxidant activity, may be a novel approach to treat the condition. The results of a clinical trial published in the September 2008 issue of the journal "Biological Psychiatry" also indicate that consuming 1 g of N-acetyl cysteine supplements twice daily for 24 weeks increases glutathione levels in the body and helps alleviate depressive symptoms.

Supplements

Glutathione supplements may be used to increase the levels of the tripeptide in the body. However, these supplements are generally expensive and may be ineffective, when taken orally. Glutathione shots may be given to treat severe cases.
Supplements containing raw materials that are used to make glutathione in the body are more effective. In fact, supplements with N-acetyl cysteine, precursors of glutathione, are the most effective over-the-counter products to enhance glutathione levels in the body, says Phyllis Balch, C.N.C.

Side Effects

The dose of N-acetyl cysteine depends upon the condition of the patient and mode of administration, so talk to a doctor to determine what is right for you. The supplements are generally safe to use, although side effects such as nausea, vomiting, rash and low blood pressure may sometimes occur. Also, its drug interactions have not been well documented, so never use supplements without first consulting a physician.