Trimethylglycine, also known as TMG or betaine, is a substance your body produces naturally that helps to break down homocysteine. Most people produce enough trimethylglycine naturally, but over-the-counter supplements and dietary sources, such as whole grains, meats and nuts, also provide trimethylglycine. Increasing your blood levels of trimethylglycine may be particularly beneficial if you have liver disease, elevated homocysteine levels or are at risk for heart disease. More research is needed, however, to examine the purported health benefits of trimethylglycine supplementation.
Consult a Doctor
The trimethylglycine dosage you require may vary depending on your health status and age. In addition, treatment with trimethylglyceine may not be appropriate if you are overweight, are taking certain medications or have kidney disease. For these reasons, seek dosing guidance from your doctor before taking trimethylglycine.
For Homocystinuria
Homocystinuria is a genetic disorder that interferes with the body's ability to metabolize an amino acid called methionine, resulting in elevated levels of homocysteine. Adults with this disease can take 6 g of trimethylglycine daily to help reduce their homocysteine levels, the University of Maryland Medical Center reports.
For Liver Disease
Treatment with 20 g of trimethylglycine daily may reduce liver inflammation in people with certain liver diseases, including nonalcoholic steatohepatitis and hepatitis. Usually, this is a long-term treatment that may last for 12 months or longer, depending on your doctor's recommendations.
For Heart Disease
If you're at risk for developing heart disease, daily treatment with 1,500 to 3,000 mg of trimethylglycine may help to protect your heart.
