Although the U.S. Food and Drug Administration banned 2,4-Dinitrophenol, or DNP, in 1938 because of severe adverse health effects, the supplement can still be found online marketed as a weight-loss aid sold under various names. Avoid this dangerous supplement.
DNP is a substance found in some supplements targeted toward bodybuilders looking to burn fat while retaining muscle. It's found for sale primarily online and commonly advertised as a safe weight-loss aid. Despite the advertising claims, DNP is anything but safe, according to the New York State Department of Health.
Metabolism Changes in Mice
DNP causes weight loss by increasing metabolism, or the amount of energy your body uses. In animals fed a high-fat diet, DNP increased metabolism by 17 percent without a change in food intake, according to an animal experiment published in the July 2014 edition of "The Journal of Biological Chemistry." After two months, the mice fed DNP weighed 26 percent less than the mice not treated with DNP. Researchers found that DNP led to fat loss without a decline in muscle mass.
Dangerous Side Effects
DNP can lead to a combination of dangerous side effects such as overheating, rapid heart rate, profuse sweating and faster than normal breathing, which can eventually lead to death. "The Journal of Analytical Toxicology" published a report in 2006 of two deaths -- one in Tacoma, Washington, and the other in San Diego -- caused by DNP. DNP was being used for weight loss in both cases and caused this dangerous combination of side effects.
Weight-Loss Supplement Safety
"Consumer Reports" urges you to steer clear of supplements containing DNP and avoid any diet product that advertises it can guarantee weight loss without diet and exercise. Long-term weight loss depends on making lifestyle changes, such as adopting a healthier diet and engaging in regular physical activity. Even prescription weight loss aids carry the risk of side effects.
- Journal of Medical Toxicology: 2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death
- The Journal of Biological Chemistry: The Chemical Uncoupler 2,4-Dinitrophenol (DNP) Protects against Diet-induced Obesity and Improves Energy Homeostasis in Mice at Thermoneutrality
- Journal of Analytical Toxicology: Two Deaths Attributed to the Use of 2,4-dinitrophenol
- ConsumerReports.org: Deadly Weight-Loss Pill DNP Is Back
- New York State Department of Health: State Health Commissioner Warns of Dangers of Weight Loss Product Deadly Dinitrophenols Available Through Internet Sales