Oxycodone and Metabolism

Oxycodone and Metabolism
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Oxycodone is a synthetic narcotic opiate pain killer that is available by prescription only for the treatment of moderate to severe pain, according to Drugs.com. Oxycodone is similar to morphine and is often prescribed for patients following major surgeries or major injuries. It relieves pain but can have side effects such as nausea, vomiting, decreased heartbeat and dizziness. Long-term use or abuse can produce serious withdrawal side effects that affect body functions. Oxycodone should only be taken under the close guidance of a physician.

Effect On Metabolism

Oxycodone and similar morphine opiates are not likely to directly have any effect on your metabolism. Although oxycodone is a central nervous system depressant, according to a study in the "Journal of Experimental and Clinical Endrocrinology," by the Department of Internal Medicine at the University of Ulm in Germany, oxycodone did not have any effect on glucose or lipid metabolism. German researchers concluded, "endogenous opiates do not influence glucose and lipid metabolism in rat adipocytes."

Indirect Effects On Metabolism

The side effects such as tiredness, constipation and loss of appetite can potentially lower your thyroid and metabolic rate. Although oxycodone may give some users a rush of energy and euphoria, other patients experience a nauseous and sleepy feeling. This fatigue, combined with constipation, another common side effect may discourage you from eating food. Furthermore, a loss of appetite is one of the most common side effects of oxycodone. According to Columbia University, not eating enough calories can lower your metabolism. If you remain on oxycodone for an extended period of time and are not eating enough calories, your metabolism may slow down.

Weight Loss or Weight Gain

Although oxycodone does not directly effect your metabolism, according to Drug Addiction Support, weight loss or weight gain are common side effects of opiates such as oxycodone. Weight loss can occur from a decrease in appetite and simply not eating the same amount of calories that you normal would. Weight gain is likely to result if you are not prone to the appetite suppression side effects but become highly inactive from taking oxycodone. Many patients that are prescribed oxycodone are recovering from major surgeries and are unable to be as physically active as they would otherwise. The severity of side effects tend to be strongest in patients that have not taken oxycodone or do not have a tolerance to opiates.

Warning

Oxycodone should only be taken under a doctor's care and used as directed. It is a highly addictive narcotic pain killer that can cause physical and psychological dependence and addiction, even if used as directed. Oxycodone has a high potential for abuse because of the feelings of euphoria it can produce in many patients. Please do not hesitate to seek treatment for oxycodone abuse, it is a common side effect among those with chronic pain. Consult your physician immediately if you are experiencing any side effects or have questions regarding oxycodone. An accidental overdose can result in death.

References

Article reviewed by Libby Swope Wiersema Last updated on: Jan 30, 2011

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