What Happens if a Vaccine Shot Misses the Muscle?

It's best to wear a short-sleeve shirt while receiving a vaccine.
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The thrill of getting an appointment for your first COVID shot might quickly be followed by worries — about side effects, maybe, or even what might happen if you're given the shot incorrectly.


Here's a quick rundown on where the jab should land, and what happens if the needle misses the mark.

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Why the Vaccine Goes in the Muscle

No matter which vaccine you get, it should be injected into the deltoid (shoulder) muscle.

Once injected, the mRNA in the Pfizer or Moderna vaccines enters muscle cells, where it instructs these cells to make a piece of the spike protein of the virus. That's what triggers the body to produce antibodies, which can then recognize and fight off the coronavirus if and when you come into contact with it.

Similarly, the one-shot Johnson & Johnson is a viral vector vaccine, which means it uses a deactivated cold virus to carry genetic info from the novel coronavirus into your muscle cells, where it creates the spike protein that triggers your immune response.

Get tips on how to stay healthy, safe and sane during the novel coronavirus pandemic.

So, What Happens if It Misses?

"It is possible to miss the muscle with the COVID-19 vaccine. That's because different arms have different amounts of fat," John Segreti, MD, medical director of infection control and prevention at Rush University Medical Center in Chicago, tells LIVESTRONG.com.


People in bigger bodies, including those who fall into very high BMI categories, may need a longer needle in order to reach the muscle. Otherwise, it's difficult to miss the deltoid muscle, Dr. Segreti says.

The Centers for Disease Control and Prevention (CDC) gives little advice on what to do if this happens and the vaccine is injected into the fat, except for telling providers not to repeat the same dose of the vaccine. (In other words, if it missed the deltoid, it's not like the vaccine "doesn't count.")


If the error happened during your first shot of a two-dose vaccine, you should still go in and get the second dose at the correct interval (21 days later for Pfizer, 28 days for Moderna).



To help make sure the shot lands where it's supposed to, wear clothing that can easily and completely expose your shoulder (rather than, say, pulling the neck of your shirt down around your shoulder).

Potential Side Effects to Watch For

If the provider thinks the shot didn't go in correctly, he or she should talk to you about potential side effects.


The nonprofit Institute for Safe Medication Practices flags a particular problem called "shoulder injury related to vaccine administration" (SIRVA). SIRVA is the result of a vaccine being injected into the shoulder joint, which can lead to inflammation that causes:

  • Pain in the arm/shoulder
  • Arm weakness
  • Range of motion problems

Shoulder pain and inflammation can be easily mistaken for an injury. If you experience shoulder pain that does not go away, tell your doctor you received the vaccine so they have this info when evaluating you.


Bottom line:​ It's not very likely that the COVID-19 vaccine would miss your muscle. Still, for many reasons, it's important to watch for side effects or reactions and report any concerns to your doctor.




Is this an emergency? If you are experiencing serious medical symptoms, please see the National Library of Medicine’s list of signs you need emergency medical attention or call 911.

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