Lisinopril Blood Pressure Medicine Side Effects

Talk to a health care professional if you notice any of these lisinopril side effects.

Lisinopril is an ACE inhibitor used to treat high blood pressure. It may also be used to treat heart failure in combination with other drugs. This drug may cause side effects that are bothersome or persistent. In some cases, these side effects may be severe enough to require a dosage adjustment or replacement of lisinopril with an alternate drug.


Skin Changes

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Lisinopril may cause itching or a mild rash on the skin. This is usually a minor side effect that will clear up on its own. However, a rash can also indicate an allergic reaction. If the rash is accompanied by redness, swelling of the face or difficulty breathing, seek immediate medical attention. One of the more serious side effects of lisinopril is yellowing of the eyes and skin. If this occurs, seek the advice of a medical professional.

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General Side Effects

There are several general side effects of lisinopril that affect the entire body. They include weakness, light-headedness and dizziness. If light-headedness is persistent or fainting occurs, seek medical attention; these are serious side effects that could indicate a serious medical condition.

Urinary System

Lisinopril can affect the urinary system in several ways. Protein in the urine and worsening of kidney disease have been reported. Lisinopril can also cause the levels of blood urea nitrogen and creatinine to increase. Painful urination, reduced frequency of urination, urinary tract infection and inability to urinate may occur.


Metabolic Side Effects

While metabolic side effects of lisinopril are rare, they can occur in some patients. The levels of potassium and serum aldosterone may increase with lisinopril therapy. People who take lisinopril with diabetes medications may experience low blood sugar levels. This medication may also lead to weight gain, weight loss, gout and fluid overload.

Nervous System

Some side affects of lisinopril affect the nervous system and how it interprets sensations. This drug can cause tremors, nerve pain, tingling sensations and spasms. Lisinopril has also been linked to memory impairment.


Cardiovascular System

Lisinopril has a number of side effects that affect the cardiovascular system. It can cause orthostatic hypotension, low blood pressure, edema and inflammation of the blood vessels. Lisinopril has also been linked to heart attack, cardiac arrest, pulmonary embolism, heart arrhythmia and stroke.

Respiratory System

The respiratory system can be affected by treatment with lisinopril. The drug has been associated with bronchitis, nosebleed, laryngitis, wheezing, pharyngitis, pleural effusion, rhinitis and coughing up blood.


Digestive System

Digestive system side effects are common with lisinopril treatment. The drug can cause gastrointestinal cramping, flatulence, constipation, heartburn, dry mouth, indigestion, vomiting and stomach inflammation. It has also been linked with hepatitis and pancreatitis.




Is this an emergency? If you are experiencing serious medical symptoms, please see the National Library of Medicine’s list of signs you need emergency medical attention or call 911.