Oven-baking is the most common way to cook any variety of lasagna. With the exception of any meat included in the recipe and the pasta, which you cook before layering with other ingredients in the baking pan, baking serves to heat the food and blend flavors rather than cook the dish to a safe level of doneness. Thus, the baking times and temperatures needed for lasagna are generally the same no matter what the recipe's ingredients are.
Adjust an oven rack so that the lasagna will be situated in the middle of your oven. This improves heat circulation and ensures that your lasagna bakes evenly.
Preheat your oven to a medium-high baking temperature of 350 to 375 degrees Fahrenheit. Allow about 30 minutes of preheating time to ensure that your oven reaches the correct temperature.
Cover the baking dish and bake the lasagna for 30 to 45 minutes or until a visual inspection shows the sauce bubbling over the top layer of pasta and cheese. Covering the pan prevents the lasagna's top layer from browning too quickly while the middle is still cooking. If your pan does not have an oven-proof cover, use a sheet of aluminum foil.
Remove the cover, sprinkle on a final layer of cheese according to your taste preference, and bake the lasagna for another 10 to 15 minutes to melt the cheese and brown the top of your lasagna.