5 LIPO-6 Side Effects to Watch Out For

There's no evidence to show that LIPO-6 has any weight-loss side effects — in fact, certain ingredients in the supplement may actually harm your health.

Perhaps you've seen fat-burning diet pills like LIPO-6 lining the shelves at a supplement shop or drugstore. But just because it's available for purchase doesn't mean it's safe — in fact, LIPO-6 side effects can potentially put your health in danger.


So, how do you use LIPO-6? According to Nutrex Researchers, the manufacturers of the LIPO pills, taking the capsule twice daily prompts your body to produce more heat, which then increases your metabolism to burn fat.

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But there's no medical research to suggest that LIPO-6 works — in reality, this and other diet supplements may not deliver the weight loss results they promise and can also cause potentially harmful side effects, per the National Institutes of Health's Office of Dietary Supplements (ODS).


What's more, these products don't go through the same rigorous testing and FDA approval as prescription drugs, according to the ODS. In other words, there's no guarantee any weight-loss supplement is safe, contains the ingredients it says it does or produces the effects it claims.

To help you stay safe, here are the LIPO pill side effects to look out for (and whether LIPO-6 even supports weight loss in the first place).



Talk to your doctor before taking LIPO-6 or any other liposuction pills, per the ODS. They can help you determine whether it's safe for you.

1. It Can Cause a Caffeine Overload

The LIPO-6 Black weight-loss pills (and other versions of the supplement) contain caffeine anhydrous, which is a powdered form of caffeine, according to the website. The manufacturer doesn't specify how much caffeine is in every LIPO-6 dosage.

In general, though, caffeine is safe in moderate amounts — which, according to the ODS, is about 400 milligrams per day (that's about four cups of coffee, for reference).


And it's possible that caffeine may indirectly help support weight loss: For instance, a February 2015 study in the International Journal of Sport Nutrition and Exercise Metabolism found that drinking coffee before a gym workout can help you exercise longer and more intensely.

But if you're sensitive to caffeine or exceed the recommended daily dose, you may experience symptoms like:


  • Nervousness
  • Feeling jittery or shaky
  • Nausea
  • Vomiting
  • Rapid heart rate
  • Trouble sleeping
  • In severe cases, seizures


These effects may also be more pronounced if the pills are taken in combination with other sources of caffeine, like coffee or soda, according to the ODS. And because it's not always clear how much caffeine is in a LIPO-6 pill, you run the risk of taking too much and experiencing symptoms.



Taking too much caffeine can also lead to an overdose, according to Mount Sinai. If you experience symptoms like breathing issues, changes in alertness, convulsions, diarrhea or irregular heartbeat, get medical care.

2. It May Lead to Heart Issues

The diet pill also contains synephrine, a stimulant naturally found in bitter orange, per the ODS. When it comes to taking lipo pills for weight loss, synephrine may slightly increase your calorie burn and decrease your appetite, but it's not known if that actually helps you shed pounds.

And besides there being a lack of data to show whether this ingredient supports weight loss, it can also produce side effects that mess with your heart. Per the ODS, these issues can include:


Similarly, another ingredient called yohimbine may be responsible for some LIPO tablet side effects. Although it's found in a number of weight-loss products, there's no evidence to show it can help you lose weight, according to ODS.

In fact, it can be dangerous if taken in doses of 20 milligrams or more, per the ODS. It can cause symptoms like:



In severe cases, taking too much of these ingredients can lead to death, according to the ODS. That's why you should always talk to your doctor before trying any diet pill.

3. It Can Cause Digestive Problems

Gastrointestinal problems are another LIPO-6 effect to be aware of, and a number of different ingredients may be to blame.

For instance, certain varieties of the supplement (like LIPO-6 Black Stim-Free) contain L-carnitine, a substance your body produces and that's naturally found in foods like meat, fish and dairy products, per the ODS. It helps your cells break down fat, which may contribute to a small amount of weight loss.


That said, taking more than 2 to 4 grams of the substance can lead to digestive distress. According to the ODS, these symptoms can include:

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal cramps
  • Fishy body odor

Other varieties of the supplement (like the LIPO-6 probiotic pill) contain digestive enzymes, according to the website. And while probiotics are generally safe and can support good digestion, it's not known whether it can help you lose weight, per the ODS. And for some, taking probiotics can cause digestive symptoms like gas and bloating.

Finally, certain forms of the diet pill (like LIPO-6 Black Thyrolean) contain an amino acid called L-tyrosine, per the website. This substance can cause an upset stomach for some, according to Mount Sinai.

4. It May Lead to Headaches

Some of the ingredients in LIPO-6 pills can also cause headaches, according to the ODS. For instance, synephrine and yohimbine can lead to head pain, along with other symptoms like:

  • Anxiety
  • Agitation
  • Muscle and bone pain

Similarly, tyrosine can trigger migraines, according to Mount Sinai. As a result, it's best for people who are prone to migraines to avoid taking the supplement so they don't experience this LIPO-6 side effect.

5. It Doesn't Mix Well With Certain Medications

The yohimbine in LIPO-6 pills may not mix well with a certain category of antidepressant medications called monoamine oxidase inhibitors, according to the National Center for Complementary and Integrative Health. If you're taking any of these medicines for depression, it's best to steer clear of the diet pill to avoid side effects.

BioPerine — or black pepper extract — may also be to blame for some LIPO-6 side effects. That's because the extract may enhance the absorption of prescription medications used to thin your blood or lower blood sugar, which can lead to higher-than-normal levels of the drugs in your system, according to a September 2021 review in ​Foods​.

This might cause your medication to have a stronger effect than desired, which can lead to various additional side effects, depending on the medication.


If you take prescription drugs, talk to your doctor before starting any diet pill to make sure it's safe for you, per the ​Foods​ review.




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