How to Take Prilosec With Probiotics

Gastric acid.
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Prilosec is the brand name for omeprazole, a protein pump inhibitor that is used to reduced the amount of acid in the stomach. The medication is available both over the counter and by prescription. The over-the-counter dosage is 20mg whereas the prescription version is available in 10mg, 20mg and 40mg dosages.


Probiotics are beneficial bacteria found in the gastrointestinal tract. The beneficial bacteria prevents harmful bacteria from causing problems. Taking probiotics and Prilosec at the same time can decrease the effectiveness of both therapies. Therefore, special care must be executed when taking Prilosec and probiotics.

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Consult your physician prior to taking Prilosec or probiotics.

Step 1

Take your Prilosec as directed by your physician. Prilosec is typically administered daily. The time of day you take Prilosec doesn't matter as long as you take it at the same time daily. Try to take your Prilosec at the same time you perform another daily task, such as brushing your teeth or eating breakfast, to remind you to take your Prilosec on time each day.

Step 2

Wait at least two hours after taking your Prilosec to take your probiotics.


Step 3

Take the probiotics as instructed by your physician. Probiotics may be taken with or without food. If you experience stomach upset, however, you may wish to take your probiotics with food.



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