Probiotics — aka good-for-you bacteria and yeast — reside in your body, delivering all sorts of health benefits. Add yogurt, kimchi or other probiotic-rich foods to your diet and you'll naturally take in these microorganisms.
But if those foods aren't appealing, you can also turn to supplements.
"Many of my patients have found benefit with probiotics," Bryan Curtin, MD, MHSc, director of the Center for Neurogastroenterology and GI Motility at Mercy Medical Center, tells LIVESTRONG.com.
"Probiotics cause benefit by multiple mechanisms," Dr. Curtin explains, adding that this includes suppressing the growth of bad bacteria, improving the gut's natural defenses and supporting the immune system of the gut.
But much more remains to be known when it comes to the positive effects of probiotics. "The major GI societies in the U.S. have made position statements that it is unclear what strains, dosing and regimens are beneficial for the general use of probiotics," Dr. Curtin says.
- For Overall Health: Kyo-Dophilus Max Probiotics ($34.53, Amazon.com)
- For Women: Rephresh Pro-B Probiotic Supplement for Women ($23.99, Amazon.com)
- For Diarrhea: Culturelle Digestive Health Daily Probiotic Capsules ($16.88, Walmart.com)
- For Constipation: Gerber Soothe Probiotic Colic Drops ($24.99, Amazon.com)
- For IBS: Visbiome High Potency Probiotics ($60.95, Amazon.com)
- For Weight Loss: Jamieson Probiotics 5 Billion ($38.78, Amazon.com)
- For Brain Health: Nature’s Way Fortify Daily Probiotic ($15.22, Amazon.com)
- For Heart Health: Dr. Mercola Complete Probiotics ($29.97, Amazon.com)
- For Immunity: GNC Probiotic Complex Daily Need ($29.99, Amazon.com)
4 Things to Look for in a Quality Probiotic
If you browse online or peruse the vitamins and supplements aisle in a drug store, you'll find many, many options. Here's what to keep in mind as you select a probiotic supplement.
This stands for colony-forming units and it's "an estimate of the number of viable cells capable of forming new bacterial colonies in the gut," says Carielle Nikkel, RDN, vice president of nutrition at Persona Nutrition.
"Doses of 5 to 20 billion CFU per day have been shown to be effective in supporting immune and digestive health," she says.
Some products will tout that they have "megadoses" of probiotics, Nikkel points out — but higher CFUs don't always equate to better health benefits, per the National Institutes of Health (NIH).
2. Brand and Certification
Choose a reputable brand before making a purchase. "Look for a brand that has doctors, dietitians and other nutrition experts working behind the scenes," Nikkel recommends.
You can also look for third-party certification on the container from organizations including:
- United States Pharmacopeia
- NSF International
"When you read the label, look for additives or allergens in the probiotic capsules that may not work for your body — especially if you have food sensitivities or dietary restrictions," says gut health dietitian Laura Poe Mathes, RD.
If the information isn't available there, you can check on the company's website or reach out for more information, she says.
4. Genus, Species and Strain
Along with an alphanumeric, bacteria are identified by their genus, species and strain, per the World Gastroenterology Organisation Global Guidelines.
Within each genus, there are many species and strains, per the California Dairy Research Foundation. These are presented in order, drilling down from the broadest category to the most specific. So, for Lactobacillus rhamnosus GG, the genus is Lactobacillus, the species is rhamnosus and the strain is GG, per the California Dairy Research Foundation.
Here are some of the most common genera found in probiotic supplements, per the NIH:
- Lactobacillus: This may help with diarrhea, as well as allergies, stomach pain and constipation, per the U.S. National Library of Medicine (NLM).
- Bifidobacterium: This bacteria may help with constipation and airway infections, per NLM.
- Saccharomyces: This yeast may be effective against diarrhea and stomach pain, per a December 2020 report from ConsumerLab.
- Streptococcus: This is effective with some forms of diarrhea, per ConsumerLab.
- Bacillus: This helps with abdominal pain, bloating and constipation, per ConsumerLab.
"The most important thing to look for is the right species of bacteria (or yeast) tailored to your specific health needs," Poe Mathes says.
The world of probiotics can be overwhelming, which is why the experts we spoke to recommended consulting with a doctor or health care provider before starting one.
“Despite their wide availability, probiotic supplements are not entirely benign agents,” Dr. Curtin says — and not everyone should take one, he notes. He recommends trying them for a short period of time (2 to 4 weeks) as opposed to taking them daily for several years.
1. Probiotics for Overall Health
If you're looking to improve your overall digestive health, an option with many strains may be appealing.
"I typically recommend supplements with multiple species in it, helping to promote the most diversity in the microbiome possible, but for some, single-strain supplements may be more appropriate," Poe Mathes says.
Kyo-Dophilus Max Probiotics ($34.53, Amazon.com)
The instructions call for you to take one of these large capsules daily. This supplement is vegetarian and does not need to be refrigerated. It contains many strains of probiotics, including Lactobacillus gasseri, Bifidobacterium bifidum, Lactobacillus plantarum and more.
2. Probiotics for Women
If you are prone to vaginal infections, there may be a preventative benefit to taking probiotics, per a December 2020 report from ConsumerLab, which provides independent test results for health and nutrition products.
This is one area where more studies are needed to sort out what's possible. Lactobacillus rhamnosus GR-1 appears to be the best probiotic for vaginal health, according to Harvard Health Publishing.
Rephresh Pro-B Probiotic Supplement for Women ($23.99, Amazon.com)
This is a ConsumerLab top pick for preventing vaginal infections. The combination of strains present in this supplement (which includes Lactobacillus rhamnosus GR-1) "reduce colonization of the vagina by potentially pathogenic bacteria," per the ConsumerLab report.
3. Probiotics for Diarrhea
"Probiotics are particularly helpful with diarrhea, especially after recent antibiotic usage," Dr. Curtin says. Lactobacillus rhamnosus GG and Saccharomyces boulardii both help cut down on antibiotics-associated diarrhea, which affects 30 percent of people who take antibiotics, per the NIH.
Culturelle Digestive Health Daily Probiotic Capsules ($16.88, Walmart.com)
Not only with this ease antibiotic-associated diarrhea, but it can also help with traveler's diarrhea, per ConsumerLab. Begin taking when you start your antibiotics course, and continue for a full week after you've completed the script, according to the ConsumerLab report.
4. Probiotics for Constipation
Struggling to go can be uncomfortable. "Probiotics can be safely tried for mild constipation, in addition to adequate hydration, fiber intake and magnesium supplementation," Dr. Curtin says.
Compared to a placebo, Lactobacillus reuteri helps improve the frequency of bowel movements, per a small December 2014 study in the Journal of Gastrointestinal and Liver Diseases. (The same effect was observed in previous studies with children.)
Gerber Soothe Probiotic Colic Drops ($24.99, Amazon.com)
As well as being effective for colic in infants, taking these drops — which contain Lactobacillus reuteri — twice a day might help reduce constipation in adults, per ConsumerLab.
5. Probiotics for IBS
Strains of Lactobacillus bacteria — including Lactobacillus plantarum, Lactobacillus bulgaricus and Lactobacillus acidophilus — may help alleviate IBS symptoms, per the Canadian Society of Intestinal Research.
Visbiome High Potency Probiotics ($60.95, Amazon.com)
Taking this large capsule may help with bloating for some forms of IBS, per ConsumerLab. It's their top pick for both reducing bloating in diarrhea-predominant IBS and for pouchitis (inflammation that can occur after surgery for ulcerative colitis, per the Mayo Clinic). Note that this product contains milk.
Although research is promising, the American Gastroenterological Association (AGA) recommends people with IBS consider holding off on taking probiotics because supplements can be pricey and there simply isn’t enough evidence to support that they’ll be beneficial (and won’t lead to harm).
6. Probiotics for Weight Loss
People with overweight or obesity are observed to have lower bacterial diversity within their gut microbiome, per a June 2018 analysis in The BMJ.
And certain probiotics may be beneficial when it comes to weight loss — Lactobacillus gasseri SBT 2055 and Lactobacillus rhamnosus ATCC 53103 as well as a combination of L. rhamnosus ATCC 53102 and Bifidobacterium lactis Bb12 are linked to reduced body weight and weight gain, per a March 2014 review in Beneficial Microbes.
However, clinical trials have had inconsistent results, per the NIH, which notes that as well as the particular strains, the characteristics of the person taking them (like their weight and sex) may play a role in the effectiveness of the probiotics.
Jamieson Probiotics 5 Billion ($38.78, Amazon.com)
A single daily capsule, which is medium- to large-sized, contains Lactobacillus gasseri as well as several other strains.
7. Probiotics for Brain Health
The gut plays a major role in your mood — so much so that it's referred to as your "second brain." The gut and your brain communicate with each other — that means psychological interventions may help with gut-related problems, per Johns Hopkins Medicine.
And the reverse may be true as well: One small study found that taking probiotics is linked to helping ease negative thoughts due to a sad mood, per August 2015 research in Brain, Behavior, and Immunity. And probiotics are linked to helping with symptoms of psychological conditions (such as depression and anxiety), per an October 2016 systematic review in the Journal of Neurogastroenterology and Motility that examined both animal and human studies.
Taking Lactobacillus acidophilus, Lactobacillus casei and Bifidobacterium bifidum were observed to ease depression symptoms in people with major depressive disorder in a small March 2016 study in Nutrition. More research is needed to understand this bidirectional gut-brain relationship.
Nature’s Way Fortify Daily Probiotic ($15.22, Amazon.com)
This one daily capsule contains several probiotic strains (including the three called out in the Nutrition study).
8. Probiotics for Heart Health
It's possible that probiotics can help with heart health, mainly through their beneficial effect on your cholesterol levels. Probiotic supplements were linked to lowered cholesterol levels in a September 2015 meta-analysis of 15 studies in Annals of Medicine — in particular, the authors called out that the Lactobacillus acidophilus strain was observed to lower LDL (aka "bad") cholesterol.
While some reviews have found that probiotics might improve lipid levels, others have found insufficient evidence, per the NIH. More research is needed to pinpoint how — and which — probiotics can help with heart health and cholesterol, but per the NIH, probiotic supplements with Lactobacillus acidophilus, Lactobacillus plantarum or a combination of Lactobacillus acidophilus and Bifidobacterium lactis are most linked to reduced LDL cholesterol levels.
Dr. Mercola Complete Probiotics ($29.97, Amazon.com)
Take one capsule (warning: it's large) in the morning. It contains both Lactobacillus acidophilus and Bifidobacterium lactis, as well as several other strains.
9. Probiotics for Immunity
A surprising amount — an estimated 70 percent — of immune cells are found in your gut, per a September 2008 article in Clinical and Experimental Immunology. What happens in your gut affects many systems in your body, including the immune system.
While more research is needed in this area, there's evidence that probiotics containing strains of Lactobacillus and Bifodobacterium are linked to reduced symptoms of colds and upper respiratory infections, per the ConsumerLab review.
For instance, in one study, participants who were prone to getting colds in the winter were divided up into two groups — one group drank a probiotic drink containing Lactobacillus paracasei, Lactobacillus casei and Lactobacillus fermentium while the other group had a placebo beverage without any probiotics. The probiotic beverage was observed to reduce the incidence of upper respiratory infections and flu-like symptoms, per the June 2018 study in Synthetic and Systems Biotechnology.
Taking probiotics may also help with inflammation — compared to a group taking a placebo, older adults taking a probiotic supplement had increased anti-inflammatory markers, per an April 2015 study in the Journal of the American College of Nutrition.
GNC Probiotic Complex Daily Need ($29.99, Amazon.com)
You'll take one large capsule a day with food. This supplement is vegetarian and both glucose- and lactose-free. It contains Lactobacillus acidophilus (CUL 60 and CUL 21), Bifodobacterium bifidum (CUL 20) and Bifobacterium animalis (CUL 34).
- Harvard Health Publishing: "Health benefits of taking probiotics"
- Office of Dietary Supplements: "Probiotics"
- World Gastroenterology Organisation Global Guidelines: "Probiotics and prebiotics"
- California Dairy Research Foundation: "Probiotics Basics"
- Consumer Labs: "Probiotic Supplements Review (Including Pet Probiotics)"
- Harvard Health Publishing: "Should you use probiotics for your vagina?"
- Journal of Gastrointestinal and Liver Diseases: "https://pubmed.ncbi.nlm.nih.gov/25531996/"
- Canadian Society of Intestinal Research: "Probiotics for Irritable Bowel Syndrome"
- American Gastroenterological Association: "AGA does not recommend the use of probiotics for most digestive conditions"
- Mayo Clinic: "Pouchitis"
- The BMJ: "Role of the gut microbiota in nutrition and health"
- Beneficial Microbes: "The development of probiotic treatment in obesity: a review"
- Johns Hopkins Medicine: "The Brain-Gut Connection"
- Brain, Behavior, and Immunity: "A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood"
- Journal of Neurogastroenterology and Motility: "Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review"
- Annals of Medicine: "Effects of probiotics consumption on lowering lipids and CVD risk factors: a systematic review and meta-analysis of randomized controlled trials"
- Clinical and Experimental Immunology: "Allergy and the gastrointestinal system"
- Synthetic and Systems Biotechnology: "Prospective study of probiotic supplementation results in immune stimulation and improvement of upper respiratory infection rate"
- Journal of the American College of Nutrition: "Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, and Bifidobacterium longum MM-2 Ingestion Induces a Less Inflammatory Cytokine Profile and a Potentially Beneficial Shift in Gut Microbiota in Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study"
- U.S. National Library of Medicine: "Lactobacillus"
- NLM: "Bifidobacterium"
- NLM: "Saccharomyces"