Gold Member Badge


  • You're all caught up!

What Are the Treatments for High Cortisol?

author image Jacques Courseault
As a physical medicine and rehabilitation physician I have extensive experience in musculoskeletal/neurological medicine that will benefit the network.
What Are the Treatments for High Cortisol?
People are working in an operating room. Photo Credit: Jochen Sand/DigitalVision/Getty Images

High cortisol levels, or Cushing's syndrome, occur when the body is exposed to high levels of cortisol, according to the National Institutes of Health. Cushing's syndrome can be caused by taking too much corticosteroid medication, or by tumors in the pituitary gland, adrenal glands or some other part of the body. Patients with high cortisol levels may experience weight gain, acne, easy bruising, backache, bone pain, impotence and fatigue. Thus, early treatment of high cortisol is necessary to improve symptoms.

Video of the Day

Adjust Medications

According to, a patient on high-dose or long-term corticosteroids should decrease steroid use to reduce high cortisol levels. A patient should never immediately discontinue using corticosteroids, but consult a doctor for a regimen to decrease current doses. A sudden decrease in corticosteroid use can result in serious complications. Slowly reducing cortisol levels will allow the adrenal glands to resume making adequate levels of cortisol.


If medications are not the cause of high cortisol levels, the source of excess cortisol release in the body needs to be detected. Tumors in the adrenal glands, pituitary glands or other organs can secrete cortisol. Thus, removal of the tumor is necessary to cure high cortisol levels.

In this case, a patient should have the proper tests done to find the source. Then, he should discuss treatments options with his surgeon, which may include surgery. The risks and benefits of each case differ; thus, a patient should thoroughly discuss these with his surgeon. In general, there is a risk of infection, excessive bleeding, soft tissue damage or organ damage. In some cases, lifelong cortisol replacement may be necessary, states Drugs commonly used include ketoconazole, mitotane and metyrapone.

Radiation Therapy

According to, radiation therapy may be necessary if a surgeon cannot fully remove a pituitary tumor. In this case, radiation therapy may be necessary after the operation. Radiation is typically given over a six-month period through a technique called stereotactic surgery or gamma-knife radiation. Radiation is isolated to the tumor, and exposure to the surrounding tissues is minimized. A patient should let his surgeon know if he experiences side effects during or after radiation therapy.

LiveStrong Calorie Tracker
Lose Weight. Feel Great! Change your life with MyPlate by LIVESTRONG.COM
  • Gain 2 pounds per week
  • Gain 1.5 pounds per week
  • Gain 1 pound per week
  • Gain 0.5 pound per week
  • Maintain my current weight
  • Lose 0.5 pound per week
  • Lose 1 pound per week
  • Lose 1.5 pounds per week
  • Lose 2 pounds per week
  • Female
  • Male
ft. in.


Demand Media