Vitamins and medications are chemical compounds that affect the body’s metabolic function. Just as medications may have toxic interactions when taken together, they may also have toxic interactions when taken with vitamins. While many patients discuss their prescribed medications with their doctors, vitamin supplements sold over the counter often are not considered. Patients are encouraged to discuss all medications, supplements and over-the-counter products with their doctor to reduce the risk of adverse interactions.
Patients with diseases of the heart and blood vessels are often prescribed blood-thinning medications called anticoagulants to prevent clots from forming in the circulation and blocking or damaging an artery or vein. Vitamin K (phytonadione) helps the body form blood clots. The most common blood-thinning medications, including Coumadin, act to block Vitamin K, inhibiting the formation of blood clots. While very low levels of vitamin K in the body can result in poor clot formation and increased bleeding, very high doses of ingested or administered vitamin K may act to counteract large doses of anticoagulants, placing the patient at risk for clot formation. Similarly, high levels of Vitamin C (ascorbic acid) may interfere with anticoagulant inhibition of the clotting pathway and lead to increased risk for clot formation.
Many types of medications are used in the treatment of high blood pressure and many interact with high levels of supplemented vitamins. Antihypertensive medications which help lower blood pressure by dilating blood vessels may be affected by increased levels of Vitamin B3 (niacin). In high doses (larger than 75 mg), niacin may dilate blood vessels and heighten the medication effects, resulting in dangerously low blood pressure. Digitalis-based drugs such as Digoxin and Diltiazem may be affected by Vitamin D via alteration in blood calcium level and may induce irregular heart beats known as arrhythmias.
Other medications which treat high blood pressure by decreasing the amount of fluid in the body, called diuretics, may be affected by vitamins. Thiazide diuretics act on the kidney to remove fluid but retain minerals such as calcium. Excessive Vitamin D ingestion while on diuretic therapy may result in increased calcium in the blood. As in other Vitamin D-drug interactions, increased blood calcium may cause abnormal heart beats called arrhythmias.
To date, the controversy surrounding vitamins and chemotherapy continues as adequate research is incomplete in determining the safety of these agents together. Many of the cancer-fighting drugs attack the cancer cells and generate free radicals; antioxidant vitamins are thought to prevent the formation of oxygen free radicals and therefore inhibit the effects of the chemotherapy. Laboratory studies to this effect are inconclusive. The best way to determine whether or not vitamin supplements should be taken during chemotherapy is to discuss their use, along with all other over-the-counter medications, with your treating physician.
- "Healing with Vitamins"; Rodale Health Books; 2008
- "Vitamins, Herbs, Minerals & Supplements: The Complete Guide"; H. Winter Griffith, M.D.; 1998
- The Merck Manuals Online Medical Library
- The PubChem Project
- "Cancer Research"; The Antioxidant Conundrum in Cancer; Seifried HE, McDonald SS, Anderson DE, et al.; 2003