Prostaglandin Inhibitor Drug List

Doctors may prescribe prostaglandin inhibitors to help fight against such diseases as cancer of the bladder, lungs, breasts and colon and rectum. Prostaglandins, essentially, are types of fatty acids that can cause inflammation, pain and swelling in various areas of the body. The production of them also can lead to more serious problems such as the formation of cancer. While drugs that prevent the production of prostaglandin can have side effects, the positive effects generally outweigh them.

A woman is browsing on her laptop. (Image: Szepy/iStock/Getty Images)


One of the oldest non-steroidal anti-inflammatory drugs, aspirin first was released to doctors to distribute to patients by the Bayer pharmaceutical company in 1899. The name “aspirin” was the brand name of the medication generically called acetylsalicylic acid. This medication can inhibit the production of prostaglandins that can cause cancer as well as more immediate problems such as pain and swelling. The most common non-serious side effects of this prostaglandin inhibitor include nausea and heartburn, reports.


Ibuprofen, another NSAID that acts as a prostaglandin inhibitor, can produce serious common side effects such as breathing difficulties, pain in the abdomen, abnormal bleeding, fatigue and diarrhea among others. People may purchase low-dose ibuprofen without a prescription over the counter, but stronger versions exist that require a doctor’s order and prescription.


This NSAID, commonly prescribed in the treatment of gout and other forms of arthritis, works similarly to other NSAIDs. It inhibits prostaglandin production which decreases inflammation, swelling and stiffness. Indomethacin can cause a mild headache as a non-serious and common side effect. Doctors may prescribe it as a capsule, intravenous medicine or as a suppository.


Celecoxib, another NSAID classified as a COX-2 inhibitor, prevents the formation of prostaglandins by blocking the cyclooxygenase-2 enzyme that makes them. This medication typically finds uses fighting the symptoms of osteoarthritis and rheumatoid arthritis. Common serious side effects include swelling in the legs, feet, face and fingers, a fever, a rash on the skin, a sore throat and coughing, as well as sneezing. The Mayo Clinic recommends seeking immediate consultation with a physician if these side effects occur.

Load Comments

Copyright © 2019 Leaf Group Ltd. Use of this web site constitutes acceptance of the LIVESTRONG.COM Terms of Use , Privacy Policy and Copyright Policy . The material appearing on LIVESTRONG.COM is for educational use only. It should not be used as a substitute for professional medical advice, diagnosis or treatment. LIVESTRONG is a registered trademark of the LIVESTRONG Foundation. The LIVESTRONG Foundation and LIVESTRONG.COM do not endorse any of the products or services that are advertised on the web site. Moreover, we do not select every advertiser or advertisement that appears on the web site-many of the advertisements are served by third party advertising companies.