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Antidepressants That Won't Cause Insomnia

author image Richard Nilsen
Richard Nilsen writes poetry, fiction, features and news stories in upstate New York. He was an emergency mental-health consultant for 20 years and directed a mentoring agency for a decade. Nilsen is a black-fly control technician in the Adirondack Park, where he enjoys hiking, biking and boating.
Antidepressants That Won't Cause Insomnia
A woman turning off an alarm clock looking unrested. Photo Credit: franck camhi/iStock/Getty Images

Ever since Prozac (generic name fluoxetine) hit the pharmaceutical market in 1987, selective serotonin reuptake inhibitors, or SSRIs, have become a popular type of antidepressant medication. Unfortunately, side effects from SSRIs include a host of difficulties from nausea to insomnia. For those who have difficulty with insomnia if Prozac is prescribed, there are other possibilities.

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Other SSRIs

Mayo Clinic staff reports that while SSRIs tend to act similarly, different ones may have different side effects depending on the individual. Therefore if one SSRI creates the insomnia side effect, switching to a different SSRI may cure the problem.


Amitriptyline, trade name Elavil, is a popular tricyclic antidepressant that may be a viable alternate for SSRIs. It works by increasing the levels of the neurotransmitters in the brain.


Tetracyclics, such as mirtazapine (trade name Remeron), work by preventing neurotransmitters from binding with nerve cell receptors called alpha-2 receptors, according to Mayo CLinic staff. By indirectly increasing the levels of norepinephrine and serotonin in the brain, it may elevate the sufferer’s mood without the likelihood of causing insomnia.

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