Antidepressants That Won't Cause Insomnia

Ever since Prozac (generic name fluoxetine) hit the pharmaceutical market in 1987, selective serotonin reuptake inhibitors, or SSRIs, have become a popular type of antidepressant medication. Unfortunately, side effects from SSRIs include a host of difficulties from nausea to insomnia. For those who have difficulty with insomnia if Prozac is prescribed, there are other possibilities.

A woman turning off an alarm clock looking unrested. Credit: franck camhi/iStock/Getty Images

Other SSRIs

Mayo Clinic staff reports that while SSRIs tend to act similarly, different ones may have different side effects depending on the individual. Therefore if one SSRI creates the insomnia side effect, switching to a different SSRI may cure the problem.


Amitriptyline, trade name Elavil, is a popular tricyclic antidepressant that may be a viable alternate for SSRIs. It works by increasing the levels of the neurotransmitters in the brain.


Tetracyclics, such as mirtazapine (trade name Remeron), work by preventing neurotransmitters from binding with nerve cell receptors called alpha-2 receptors, according to Mayo CLinic staff. By indirectly increasing the levels of norepinephrine and serotonin in the brain, it may elevate the sufferer's mood without the likelihood of causing insomnia.

Load Comments

Copyright © 2019 Leaf Group Ltd. Use of this web site constitutes acceptance of the LIVESTRONG.COM Terms of Use , Privacy Policy and Copyright Policy . The material appearing on LIVESTRONG.COM is for educational use only. It should not be used as a substitute for professional medical advice, diagnosis or treatment. LIVESTRONG is a registered trademark of the LIVESTRONG Foundation. The LIVESTRONG Foundation and LIVESTRONG.COM do not endorse any of the products or services that are advertised on the web site. Moreover, we do not select every advertiser or advertisement that appears on the web site-many of the advertisements are served by third party advertising companies.