Sublingual Vitamin B12 vs. Injectable B12

Your body uses vitamin B-12 to synthesize DNA and to keep your nerves and blood cells healthy. If you have a vitamin B-12 deficiency, your doctor may prescribe a supplement because deficiency in this vitamin can cause serious health problems such as anemia. Vitamin B-12 is available in several forms, including parenteral, which is injected by a physician, and sublingual, which dissolves under the tongue.

Your doctor may prescribe B-12 supplementation. Credit: Minerva Studio/iStock/Getty Images

Advantages to Sublingual B-12

Sublingual medications are absorbed through the mucosa beneath the tongue. Credit: Todd Arena/Hemera/Getty Images

Sublingual vitamin B-12 supplementation can be effective for patients who experience issues with other B-12 supplementation methods such as injections. Patients experiencing diarrhea or vomiting can typically tolerate sublingual B-12 administration because medications that are absorbed sublingually are able to enter the body without going through the gastrointestinal system.

Disadvantages to Sublingual B-12

You may need a reminder to take your sublingual B-12 daily. Credit: dbvirago/iStock/Getty Images

Unlike the vitamin B-12 injection, sublingual vitamin B-12 may result in an unpleasant taste because the substance must remain under your tongue until it is completely dissolved. However, it is possible to create sublingual medications with pleasant tastes. The other disadvantage to sublingual B-12 is that most patients would need to ingest the supplement daily, which could be difficult for some people to remember, as with any daily self-administered medication.

Advantages to Injectable B-12

You do not need to take a vitamin B-12 supplement each day if you receive injectable B-12 from your doctor. Credit: ferlistockphoto/iStock/Getty Images

Injectable B-12 is a widely used treatment for vitamin B-12 deficiency, so your healthcare provider is most likely very familiar with this form of supplementation. A healthcare practitioner must administer this method of vitamin B-12 supplementation, so it is easily supervised and monitored, making it less likely for you to make a dosage error. Further, with injectable vitamin B-12, you do not have to remember to take a supplement each day, unlike the sublingual method.

Disadvantages to Injectable B-12

B-12 injections may be painful. Credit: Monkey Business Images Ltd/Monkey Business/Getty Images

While injectable B-12 is a commonly prescribed treatment for vitamin B-12 deficiency, it does have some notable drawbacks. Because vitamin B-12 injections are intramuscular, they can be difficult to administer to thin patients. Injections are also known to be painful, which may cause some patients to abandon treatment. Moreover, elderly or disabled patients may have difficulties traveling to a physician's office for injection administration or affording the treatment if they don't have insurance to cover it.

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