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Side Effects of Taking Too Much Aspirin

author image Ruth Coleman
Based in North Carolina, Ruth Coleman has written articles and manuals for more than 25 years. Her writing has appeared in community newspapers and places of employment. Coleman holds a Bachelor of Science in biology from Salem College, a Doctor of Medicine from Ross University and is the recipient of numerous academic awards.
Side Effects of Taking Too Much Aspirin
A doctor consults with a patient in an exam room. Photo Credit: Plush Studios/Blend Images/Getty Images

Aspirin is a medication that can be bought over-the-counter and is taken to relieve pain, lower a fever and fight inflammation. It is also used to lower risk of heart attack, stroke, heart disease and arthritis. However, side effects can occur from taking too much aspirin.

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What is Aspirin?

Aspirin is a nonsteroidal anti-inflammatory drug, or NSAID. It interferes with the cyclooxygenase-1 and cyclooxygenase-2 enzymes. These enzymes are proteins that promote cell activity. The cyclooxygenase-1 enzyme protects the stomach lining and stimulates platelets in your blood to clot. The cyclooxygenase-2 enzyme is involved with producing substances that contribute to inflammation. Aspirin reduces clot formation and fights inflammation.

Stomach Issues

Because aspirin interferes with the protection of the stomach lining, it can cause digestive side effects. Taking aspirin can cause an upset stomach, inflammation in your stomach and ulcers that can bleed or cause holes in your stomach. Some types of aspirin have a coating to help prevent damage to the stomach. Because aspirin reduces blot clotting, it can also lead to increased bleeding caused by damage to your stomach lining, or with other injury.

Acute Overdose

Taking at least 150 mg of aspirin for each kilogram of weight can lead to severe toxic side effects. This is referred to as an acute overdose. Symptoms include nausea, ringing in the ears and fast breathing. Symptoms can progress to fever, seizures, mental confusion, muscle abnormalities, kidney failure and even respiratory failure. Seek immediate medical attention if you overdose on aspirin.

Chronic Overdose

People can also develop serious side effects after taking high doses of aspirin for several days, which is known as chronic overdose. This occurs more often in the elderly population. In a chronic overdose, people can become mentally confused. They may also develop a fever, have low blood pressure and become dehydrated. In some cases, fluid may accumulate in the lungs.

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