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Is It Okay to Take Metformin & Folic Acid?

author image April Khan
April Khan is a medical journalist who began writing in 2005. She has contributed to publications such as "BBC Focus." In 2012, Khan received her Doctor of Public Health from the University of Medicine and Dentistry of New Jersey. She also holds an Associate of Arts from the Art Institute of Dallas and a Master of Science in international health from University College London.
Is It Okay to Take Metformin & Folic Acid?
Metformin can be taken safely with folic acid.

You need to consume a regular amount of folic acid per day to prevent folic acid anemia or folic acid deficiency. The prescription drug metformin is mainly prescribed to people with Type 2 diabetes, and it is safe to take along with folic acid.

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Metformin is a medication that helps control blood glucose levels. Type 2 diabetics who are noninsulin-dependent are often prescribed metformin, and metformin may be given to treat other conditions such as polycystic ovary syndrome. Women with this condition have a higher insulin level that normal and run an increased risk of developing diabetes.

Folic Acid

Folic acid supplements, in addition to folate-rich foods, work to prevent or treat folic acid deficiency, minimizing the risk of developing folic acid anemia. During pregnancy, women are required to take folic acid supplements to minimize the risk of birth defects. According to, folic acid does not interact with metformin, so you can take both together safely. However, you should consult with your physician if you are taking multivitamins that contain folic acid or if you are taking any other medication.


Although there are no known drug interactions between folic acid and metformin, if you do not feel comfortable taking both medications together, take your folic acid in the morning along with a meal and your metformin at a later time with a separate meal. Do not exceed your prescribed dose of metformin or folic acid since exceeding either can have adverse effects on your health.


If you are taking folic acid or metformin and experience symptoms such as shortness of breath, nausea, vomiting, severe headache, abdominal pain, diarrhea, constipation or lightheadedness, seek emergency care immediately. These are symptoms of a severe allergic reaction called anaphylaxis. Anaphylaxis left untreated can result in respiratory arrest or cardiac arrest.

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