The Best Vitamins and Supplements That Won't Upset a Sensitive Stomach

Many of us experience an uncomfortable side effect when popping vitamins or supplements — you know, that unsettling feeling in our stomach. Yet more than four out of five Americans currently take these diet boosters. So should you give up your daily supp to help spare your stomach?

Vitamins or supplements that are food-based can be safe for people with a sensitive stomach.
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Read more: Foods to Soothe an Upset Stomach

Why Can Supplements Cause an Upset Stomach?

People with a sensitive stomach may be more prone to abdominal discomfort when taking dietary supplements. After all, between 60 to 70 million Americans are affected by all types of digestive diseases such as ulcerative colitis, Crohn's disease and irritable bowel syndrome (IBS), states the National Institute of Diabetes and Digestive and Kidney Diseases.

"The severity of an upset stomach can vary from mild nausea to severe cramping, and this can occur within minutes of ingesting the supplement," Nicole Avena, PhD, assistant professor of neuroscience at Mount Sinai School of Medicine and visiting professor of health psychology at Princeton University, tells She adds that in many instances, the difficult-to-digest vitamins and minerals include iron, vitamin C and vitamin D.

Avena further explains that people living with gastrointestinal (GI) issues or people who simply cannot tolerate taking vitamins and minerals in supplement form face an ongoing dilemma. Their sensitive GI system might be preventing them from properly absorbing dietary supplements, yet not taking supplements (such as a multivitamin) could lead to possible long-term nutrient deficiencies.

To counteract this reaction, first, make sure you're taking the supplement as directed on the label since most vitamins should not be taken on an empty stomach. Also, consult with your physician to figure out if nausea is your body's way of signaling that your system is overloaded with one (or more) of the three common culprits (iron, vitamin C and/or vitamin D).

Yet if you're searching for a new brand or formula, there are other supplements on the market that are likely to be more stomach-soothing.

Read more: Are Supplements Safe? Here's What You Really Need to Know

Best Vitamins and Supplements for a Sensitive Stomach


"Taste can contribute to nausea, so opt for a gummy, like Vitafusion MultiVites, which comes in different fruit flavors and is easy to take," suggests Avena. This daily supplement does not contain the other troublesome tummy ingredients, including artificial sweeteners, high-fructose corn syrup, gluten, dairy, soy and synthetic dyes."

Melt-in-Your Mouth Tablets

Avena advises finding a vitamin or mineral supplement that dissolves on the tongue, which is also referred to as a sublingual supplement. EZ Melts Multivitamins are designed to melt in your mouth (no water necessary) as the active ingredients are absorbed into the system right away — even before making their way to the digestive tract. These supplements are GMO-free, as well as free of dyes, gluten and sugar.

Food-Based Tablets

While this tablet needs to be swallowed, the makers of Rainbow Light Women's One Multivitamin state that their food-based supplement is formulated to be gentle on the stomach and digestive system. One reason: It contains 25 million CFU (colony-forming units), which are live gut-beneficial probiotics that can decrease the number of "bad" bacteria in the intestines while replacing it with "good" bacteria. Also, this supplement is free of dairy, sugar, soy, nuts, yeast and fish, along with the fact that it can be taken with or between meals.

Liquid Supplements

Drinking your daily dose of essential vitamins and minerals instead of gagging on a pill might put nausea to rest. Garden of Life Vitamin Code Liquid Multivitamin is made from vitamins and minerals derived from 46 nutrient-dense foods like quinoa and chia seed sprouts. It's also free of dairy, gluten, artificial flavors, sweeteners, colors and preservatives.

Read more: Eating for Energy: 3 Nutrients That Can Put a Pep in Your Step

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