How to Discontinue Seroquel

Stopping Seroquel without talking to a doctor first could prove risky. Seroquel, or quetiapine fumarate, is a FDA (Food and Drug Administration) approved prescription medication used to treat bipolar disorder and schizophrenia. The drug is considered an "atypical antipsychotic" and helps stabilize moods by decreasing symptoms such as delusions and hallucinations. Seroquel is sometimes used to treat anxiety and sleeping disorders although the FDA has not approved it for these problems. Seroquel is not a habit-forming drug, therefore withdrawal symptoms are not considered dangerous. Discontinuing this medication should be done under the direct care of a physician.

An anxious woman is talking to her doctor. (Image: AlexRaths/iStock/Getty Images)

Step 1

Talk to your physician prior to stopping any atypical antipsychotic medication. Ask him to explain the pros and cons of discontinuing this medication. Tell your physician all other medications you are currently taking. If you are experiencing adverse side effects from taking Seroquel be sure to let your physician know. It may be possible to resolve the problem.

Step 2

Discuss with your doctor the possible side effects that may occur during this cessation period. The side effects of stopping Seroquel are usually mild. Symptoms such as nausea, vomiting and insomnia are considered rare. The return of previous mental symptoms or a psychotic episode is of greatest concern. Ask about treatment options if side effects arise.

Step 3

Design a plan along with your physician to stop taking the medication. The plan typically calls for a gradual decrease in medication. It is possible the physician may want to start an alternative medication. Follow the physician care plan as discussed, and call him if any questions or concerns arise.


Return to the physician office if you experience long lasting, severe or unusual side effects.

Conditions such as schizophrenia and bipolar disorder need lifelong monitoring and treatment. Discuss other options if your current medication regimen isn’t working for you.


Do not give any leftover medications away. Seroquel should only be taken under the direct supervision of a physician.

Never attempt to stop taking a prescription medication without a physician’s approval.

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