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Antihistamines to Relieve Ear Pressure

author image Emily DeSerio
Emily DeSerio has been a freelance writer since November 2009. DeSerio works in the mental health field as a clinical social worker. She began her higher level education at the University of South Florida (USF) with a B.A. in English and went on to complete a Master of Social Work degree at USF as well.
Antihistamines to Relieve Ear Pressure
Loratadine is a common antihistamine used to relieve ear pressure.

Ear pressure is commonly the result of fluid buildup in the middle ear, or pressure from an infection or allergic reaction, notes Antihistamines are used to treat allergies and to reduce the amount of sinus mucus. Antihistamines that can alleviate ear pressure include diphenhydramine, doxylamine and loratadine, according to These have various side effects and classifications for pregnant or breastfeeding women, and should not be used without first consulting a doctor.

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Diphenhydramine, or Benadryl, is an older antihistamine that is very powerful and effective at reducing the amount of fluid throughout the head, according to The most significant side effect of this drug is sleepiness. Diphenhydramine users should not operate heavy machinery or drive a vehicle. Other side effects are dry mouth, dizziness, headaches and difficulty urinating, according to Stomach ulcers, hyperthyroidism, asthma heart problems or glaucoma are all conditions that can be negatively affected by this antihistamine, and those suffering from these conditions should discuss the drug's use with their doctor.


Doxylamine, an active ingredient in NyQuil, is considered a first-generation antihistamine, according to Doxylamine is used as single drug or in combination with other drugs, depending on the symptoms. This drug is not recommended for children under 2, and should be used with caution for children over 2. Doxylamine should be taken with caution by those with kidney disease, an enlarged prostate, bronchitis, stomach ulcers or glaucoma. This drug also causes severe drowsiness which can lead to difficulty paying attention. It should not be used while operating a vehicle or machinery.


Loratadine, brand name Claritin, is a newer antihistamine used prevent and treat ear pressure due to allergies, according to Loratadine is available over-the-counter and typically comes in a single 24-hour dose. This drug does not cross into the brain, and therefore does not cause drowsiness in healthy adults. Those with kidney or liver disease should talk with a health care provider before taking this drug. Loratadine is most effective when taken consistently over a few days, and takes up to two hours before affecting the body, according to

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