Gold Member Badge


  • You're all caught up!

Drugs That Cause Restless Leg Syndrome

author image Marcia Veach
Marcia Veach attended Mt. Hood Community College and the University of Oregon and holds degrees in both physical therapy and journalism. She has been an active health care professional for over 30 years and a freelance writer for more than a dozen years. She has served as a writer and editor for business, nonprofit and health publications.
Drugs That Cause Restless Leg Syndrome
A pharmacist is talking to her customer. Photo Credit: Wavebreakmedia/iStock/Getty Images

Restless legs syndrome, or RLS, is the term given to a medical condition whereby people have crawly, tingly or pulling sensations in their legs, or an overwhelming urge to move their legs. The sensations usually occur during periods of inactivity, such as when a person has been sitting at a desk for a while or at night after lying down. While the exact cause of RLS is still unknown, it sometimes runs in families, so some researchers are seeking a genetic link. The National Heart Lung and Blood Institute points to research indicating that iron deficiency or the brain’s inability to make good use of this essential mineral is a precipitating factor in the disease. Some drugs are also considered culprits in bringing on the symptoms of RLS.

Video of the Day

Prescription Drugs

While the cause of primary RLS is unknown, a variety of prescription medicines are associated with increased complaints about the symptoms of the disease. According to, these prescription drugs include such antinausea drugs as Compazine and Reglan, anti-seizure medicines such as phenytoin, and some antipsychotic drugs or tranquilizers, such as haloperidol. While some types of antidepressants, such as selective serotonin reuptake inhibitors, occasionally appear to lessen the symptoms of RLS, says, they are more likely to aggravate them.

Over-the-Counter Drugs

Over-the-counter cold and allergy medicines may also bring on restless legs syndrome. In a 2008 Johns Hopkins University study reported in Medical News Today, researchers discovered that a main component of allergy medicine, diphenhydramine, made RLS symptoms three to four times worse in people who were known to have the disease. The researchers found that people who have RLS have more receptors in their brains for this type of antihistamine, which affects their nervous system and sleep-wake cycle.

Other Substances

While not medications, certain substances, such as caffeine and alcohol, also tend to worsen the symptoms of RLS, according to the Restless Legs Syndrome Foundation. The Foundation recommends avoidance of coffee, tea, soft drinks, chocolate and alcohol, especially later in the day, when it’s more likely that they won’t have been eliminated from the body before bedtime.

LiveStrong Calorie Tracker
Lose Weight. Feel Great! Change your life with MyPlate by LIVESTRONG.COM
  • Gain 2 pounds per week
  • Gain 1.5 pounds per week
  • Gain 1 pound per week
  • Gain 0.5 pound per week
  • Maintain my current weight
  • Lose 0.5 pound per week
  • Lose 1 pound per week
  • Lose 1.5 pounds per week
  • Lose 2 pounds per week
  • Female
  • Male
ft. in.


Demand Media