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Sulphur Supplement Side Effects

author image Rae Uddin
Rae Uddin has worked as a freelance writer and editor since 2004. She specializes in scientific journalism and medical and technical writing. Her work has appeared in various online publications. Uddin earned her Master of Science in integrated biomedical sciences with an emphasis in molecular and cellular biochemistry from the University of Kentucky College of Medicine.
Sulphur Supplement Side Effects
Woman with a headache holding her head Photo Credit: Martinan/iStock/Getty Images

Sulfur is a naturally occurring mineral that may be beneficial in the treatment of skin disorders, arthritis and interstitial cystitis, an inflammatory bladder condition. There are two major forms of sulfur supplements: MSM, or methylsulfonylmethane, and DMSO, or dimethyl sulfoxide. Talk with your medical provider about sulfur supplement side effects before beginning treatment.

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Stomach Irritation

The most common side effect of DMSO and MSM sulfur supplements is stomach irritation. After taking a dose of sulfur, you may experience nausea, vomiting or appetite loss. Bowel movement changes, such as constipation or diarrhea, may also occur during treatment. Constipation or diarrhea may also cause stomach cramping, pain or fullness. These side effects of sulfur supplements are typically temporary and resolve with continued use of this treatment. If you experience chronic or recurrent episodes of diarrhea or constipation, seek care from a doctor.

Headache or Dizziness

While taking DMSO supplements, you may experience headache or dizziness, the University of Maryland Medical Center warns. Sensations of dizziness may cause you to feel unstable while standing or walking. If dizziness occurs, remain seated until this sensation passes in order to limit your risk of injury from tripping or falling. Headache pain may also negatively affect your ability to concentrate on daily tasks. Consult a medical professional if these side effects persist or become bothersome.


Treatment with a DMSO sulfur supplement may cause drowsiness, "Arthritis Today" magazine reports. Excessive drowsiness may diminish your ability to remain active and alert throughout the day.


If you have a severe allergy to sulfur, you should not take supplements that contain this mineral. Improper use of sulfur supplements by hypersensitive people may induce a life-threatening allergic reaction called anaphylaxis. Symptoms of anaphylaxis include oral swelling, hives, breathing problems, upset stomach and loss of consciousness. Seek emergency medical care if you exhibit these symptoms after taking a dose of sulfur.

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