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Nicotinamide adenine dinucleotide, commonly referred to as NADH, is the active form of vitamin B-3. It is normally produced in your body. While natural forms of NADH are present in the muscles of cattle, poultry and fish, your body may not be able to make use of this form of NADH. If you need to increase the levels of NADH in your body, your doctor may recommend treatment with a supplemental form of NADH. Talk with your medical provider about the safety and beneficial aspects of treatment before beginning treatment with NADH supplements.

Safety Concerns

There are no known safety concerns associated with NADH supplement treatment at 5 mg daily or less, according to Winchester Hospital. But the long-term safety of this supplement has yet to be fully evaluated in humans. Consult your physician immediately if you develop any unusual health problems while receiving treatment with NADH supplements.


NADH is a natural health supplement and has a variety of purported health benefits. Though additional research in humans is necessary, the most current research suggests NADH supplementation may be beneficial in the treatment of Alzheimer's disease, Parkinson's disease and chronic fatigue syndrome, reports. This supplement may help reduce fatigue by increasing the amount of energy available in the body. Additionally, NADH supplements may improve nerve signaling in the brain, which may diminish symptoms associated with Parkinson's or Alzheimer's disease; however, the exact way in which these supplements work in the body is not currently known.


The safety and efficacy of NADH supplements have not been evaluated in pregnant or breast-feeding women. As such, this population of women should avoid using NADH supplements unless otherwise instructed by a medical professional.

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