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Risks of Lipase Supplements

author image Chad Stone
Chad Stone is a medical scientist based in the Pacific Northwest. Since 2003, Dr. Stone has has published high-profile articles on the molecular mechanisms of cardiovascular disease and cancer in journals such as Blood and the Journal of the American Heart Association. Dr. Stone is a specialist in blood biology as well as cancers of breast, colon, kidney and other tissues.
Risks of Lipase Supplements
You may lose some sleep. Photo Credit: tab1962/iStock/Getty Images

Lipase is a digestive enzyme made by the pancreas that helps to break down certain fats. Most people do not need to take lipase supplements because our bodies naturally make ample lipase, but some people with cystic fibrosis or celiac disease may benefit from taking lipase. Lipase supplements are generally very safe and free of dangerous side effects. However, lipase does have some mild side effects which you should discuss with your physician before you take it.

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Allergic Reactions

The most severe danger of lipase supplements is the risk of severe allergic reaction, or anaphylactic shock. According to, an online drug information resource, many lipase supplements are derived from pigs. People with allergies to pig proteins should avoid lipase unless specifically prescribed a non-porcine lipase preparation. Severe allergic reactions are very dangerous and potentially life threatening. warns that the symptoms of a severe allergic reaction include skin rashes, hives, rapid heartbeat, trouble breathing and sweating. Seek emergency assistance if you believe you are having an allergic reaction to lipase.

Neurological Side Effects

There are some potential neurological side effects of taking lipase, particularly if the lipase supplement contains other digestive enzymes such as amylase and protease. lists a number of the neurological side effects that can occur while using lipase. These effects include blurred vision, nervousness, agitation, decreased sleeping and enlarged pupils. Be sure to report any unusual neurological reactions to your physician.

Gastrointestinal Issues

As lipase is a digestive enzyme, it may disrupt some of the normal functions of your digestive system. The University of Maryland Medical Center notes that stomach problems such as upset stomach and diarrhea are common side effects of lipase supplements. Nausea is also a possible effect of taking lipase. In severe cases, lipase may cause severe intestinal cramping and stomach pain.

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