Gold Member Badge


  • You're all caught up!

Overdose Signs of Zyrtec

author image Laura Altobelli, MS
Laura Altobelli is a full-time senior editor for GSW Worldwide, an advertising agency serving the pharmaceutical industry. With a master's degree in scientific communication and more than 20 years of professional experience, Altobelli has worked with physicians, lawyers, veterinarians and architects to develop content for professional symposia and such publications as "Annals of Internal Medicine," "Journal of Trauma" and "Clinical Infectious Diseases."
Overdose Signs of Zyrtec
Overdose of cetirizine, whether accidental or intentional, may require emergency treatment.

“Dry as a bone, red as a beet, hot as a hare, mad as a hatter, and blind as a bat” is an old saying that emergency room doctors used to describe patients who had taken excessive quantities of antihistamines. Fortunately, Zyrtec, also known as cetirizine, belongs to a newer class of antihistamines that produce far less dramatic signs of overdose. Small, accidental overdoses can usually be managed at home, but you should contact your doctor or local poison control center for guidance. If you or your loved one has ingested more than three times the normal therapeutic daily dose, don’t hesitate to call paramedics.

Video of the Day


Extreme drowsiness is the most common sign of cetirizine overdose in adults. In the manufacturer’s insert found in packages of Zyrtec, Pfizer Inc. describes an adult who became deeply sedated after taking 150mg of the drug (15 times the recommended daily dose); the individual showed no other signs of overdose, and results of blood work showed no abnormalities. Drowsiness may be even more extreme in young children; parents should contact their local poison control center immediately if their child becomes unresponsive or if they suspect the child ingested Zyrtec-D, an adult formulation that contains pseudoephedrine. Pseudoephedrine is a decongestant additive that may be fatal when taken in large doses by children under the age of 12.

Restlessness, Nervousness and Irritability

A child who ingests excessive quantities of cetirizine may become restless and irritable before extreme drowsiness sets in. In a 1997 case study that appeared in the “Journal of Allergy and Clinical Immunology,” an 18-month-old boy who accidentally ingested more than 50 times the prescribed dose was given ipecac syrup and admitted to the hospital for observation. He reportedly “became slightly agitated, excitedly running around the ward in a lively manner” for approximately 2 hours.

Other Signs

Dizziness, nausea, and dry mouth have also been reported in rare instances of cetirizine overdose. Cardiac arrhythmias, such as irregular heartbeat and palpitations, may occur with overdose of Zyrtec-D, but these symptoms are most likely due to excessive intake of pseudoephedrine, not cetirizine.

LiveStrong Calorie Tracker
Lose Weight. Feel Great! Change your life with MyPlate by LIVESTRONG.COM
  • Gain 2 pounds per week
  • Gain 1.5 pounds per week
  • Gain 1 pound per week
  • Gain 0.5 pound per week
  • Maintain my current weight
  • Lose 0.5 pound per week
  • Lose 1 pound per week
  • Lose 1.5 pounds per week
  • Lose 2 pounds per week
  • Female
  • Male
ft. in.



  • “Drug Safety;" Safety of Antihistamines in Children; Ten Eick; February 2001
  • Pfizer Inc.: US Product Insert
  • “Disposition of Toxic Drugs and Chemicals in Man,” 5th edition; Randall C. Baselt; 2000.
Demand Media