Resveratrol, a natural polyphenolic compound, is produced by a variety of plants, such as grapes, peanuts and some berries, in response to various biotic and abiotic stresses, including stress, injury, UV-radiation and bacterial and fungal infection. Emerging scientific evidence suggests that resveratrol might be a potent anticancer candidate. The antitumor actions are largely attributed to the antioxidant property of resveratrol. It is also available as a dietary supplement. Consult your doctor to determine whether resveratrol supplements are safe for you.
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As of 2011, there have not been many clinical trials and observations to determine the optimal pharmacological doses of resveratrol. The results of several animal studies conducted by the New York Langone Medical Center suggest that daily doses of 500mg of resveratrol might be safe and potent.
Standardized Grape Seed Extract
Resveratrol from grape seeds has been widely studied for its potential chemopreventive and therapeutic effects. Grape seeds are preventive agents against various human diseases associated with free radicals, including diabetes, heart disease and cancer. Grape seed extract is available as a supplement in several forms such as capsules, tablets and liquid extracts. The University of Maryland Medical Center recommends 25mg to 150mg of a standardized grape seed extract per day to protect your body from oxidative damage caused by free radicals.
Optimal Therapeutic Dosage
Although resveratrol reportedly prevents or treats many human ailments in animal models, few published studies have examined the optimal therapeutic dosage. For adults, the recommended dose for resveratrol supplementation is 40mg daily, according to Dr. Johan Auwerx, a resveratrol researcher at the Huntington College of Health Sciences. Preliminary studies reviewed by the Linus Pauling Institute at Oregon State University have shown that trans-resveratrol is absorbed more efficiently by the body, but more studies are needed to evaluate the bioavailability of these interesting polyphenols in humans.
As of 2011, the most recent evidence suggests that resveratrol has no prominent side effects. However, further studies are needed to ensure its safety for pregnant and nursing women. Be on the safe side and avoid its use until more information is available. Resveratrol is a natural supplier of estrogen, a female reproductive hormone that fuels the development of breast cancer. Therefore, women at high risk of breast cancer should not consume resveratrol. Resveratrol may also decrease the therapeutic effects of anticoagulants, such as warfarin, and could increase the risk of bleeding.