While a single slice of pizza won't necessarily cause you to go over your daily calorie allotment, multiple slices might, especially if you choose a pizza with a thick crust and lots of meat and cheese. The healthiest option is a thin-crust vegetable pizza with only half the cheese of a regular pizza.
The crust makes a difference in the calories in your slice of pizza. A thin-crust slice of a 14-inch cheese pizza contains 230 calories, a slice of regular-crust cheese pizza has 285 calories and a thick-crust slice of cheese pizza provides 312 calories.
Topping your pizza with meat increases the calories, but the type of meat doesn't make a large difference in the calorie count. A slice of a 14-inch sausage pizza with a regular crust has 324 calories, and a similar slice with pepperoni has 313 calories. Choose a 14-inch meat and vegetable pizza and each slice contains 332 calories.